Key result
Severe carotid stenosis or occlusion increased the risk of 90-day stroke after TIA compared to <50% stenosis (17.2% vs 5.4%; HR 3.3; 95% CI 1.5-7.4; P=0.002).
Why the study?
Does the ABCD2 score, carotid stenosis, or atrial fibrillation predict early recurrent stroke in patients with TIA?
Population
700 nonspecialist-suspected TIA cases from the North Dublin city population
Design
Cohort
Follow-up
90 days
Authors
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Highlights carotid imaging for TIA risk stratification; leaves open whether revascularization improves 90-day outcomes.
Cohort (n=443)
No
Does the ABCD2 score, carotid stenosis, or atrial fibrillation predict early recurrent stroke in patients with TIA?
Hazard Ratio: 3.3 (95% CI 1.5–7.4)
Absolute Event Rate: 17.2% vs 5.4%
p-value: p=0.002
Carotid stenosis is a strong predictor of early stroke after TIA, whereas the ABCD2 score has limited utility in confirmed TIA cases and should be used with caution.
Sheehan et al. (2010) conducted a cohort in Transient ischemic attack (TIA) (n=443). Severe carotid stenosis or occlusion vs. <50% carotid stenosis was evaluated on 90-day stroke (HR 3.3, 95% CI 1.5-7.4, p=0.002). Severe carotid stenosis or occlusion increased the risk of 90-day stroke after TIA compared to <50% stenosis (17.2% vs 5.4%; HR 3.3; 95% CI 1.5-7.4; P=0.002).
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