Key result
Transgenic overexpression of sarcospan in Duchenne muscular dystrophy mice improved cardiomyofiber cell adhesion, sarcolemma integrity, and cardiac functional parameters.
Why the study?
Does sarcospan overexpression improve cardiac disease symptoms in Duchenne muscular dystrophy mice?
Population
SSPN-null mice and Duchenne muscular dystrophy mice (mdx)
Comparison
Transgenic overexpression of sarcospan or SSPN… vs Wild-type mice or non-transgenic mdx mice
Design
Preclinical
Follow-up
2 weeks
Authors
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Sarcospan overexpression may benefit DMD cardiomyopathy models; hypothesis-generating for human translation, should not yet change practice.
Does sarcospan overexpression improve cardiac disease symptoms in Duchenne muscular dystrophy mice?
Sarcospan overexpression improves cardiac function and sarcolemma integrity in a mouse model of Duchenne muscular dystrophy cardiomyopathy.
Parvatiyar et al. (2015) studied Duchenne muscular dystrophy cardiomyopathy. Transgenic overexpression of SSPN vs. Control mice was evaluated on Cardiac enlargement, cardiomyocyte hypertrophy, fibrosis, and sarcolemma integrity. Transgenic overexpression of sarcospan in Duchenne muscular dystrophy mice improved cardiomyofiber cell adhesion, sarcolemma integrity, and cardiac functional parameters.
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