Key result
Persistent activation of compensatory signaling pathways in the heart leads to cardiac dysfunction and cardiomyopathy, representing a key target for therapeutic research.
Design
Review
Authors
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Should not alter clinical management of cardiomyopathy; leaves open targeted validation of maladaptive signaling pathways.
This review summarizes the cellular mechanisms and signaling pathways underlying the transition from compensatory cardiac adaptation to cardiomyopathy.
Harvey et al. (2011) conducted a review in Cardiomyopathy. Persistent activation of compensatory signaling pathways in the heart leads to cardiac dysfunction and cardiomyopathy, representing a key target for therapeutic research.
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