Key result
Intraarterial injection of SCX fraction I from saline-loaded dogs increased the constrictor response to norepinephrine by 101% and significantly elevated blood pressure (p<0.01).
Why the study?
Does plasma extract from saline-loaded dogs increase vascular reactivity in rat cremaster arterioles?
Does plasma extract from saline-loaded dogs increase vascular reactivity in rat cremaster arterioles?
p-value: p=<0.05
Plasma extracts from saline-loaded dogs contain a vascular-sensitizing factor that increases vascular reactivity to constrictors and raises blood pressure, potentially representing a natriuretic hormone.
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Identifies a circulating sensitizing factor in volume-expanded plasma; leaves open its identity and relevance to human hypertension.
Plunkett et al. (1982) studied this question. SCX fraction I from saline-loaded dogs (FI-S) vs. Fraction I from hydropenic dogs (FI-H) was evaluated on Constrictor response to norepinephrine (p=<0.05). Intraarterial injection of SCX fraction I from saline-loaded dogs increased the constrictor response to norepinephrine by 101% and significantly elevated blood pressure (p<0.01).
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