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Administration of an aqueous methanol/water extract of the Oriental crude drug "maō" (Ephedra), Ephedra distachya herbs, caused transient hyperglycemia followed by long lasting hypoglycemia in mice. Activity-guided fractionation of the extract led to isolation of five glycans, ephedrans A, B, C, D and E, which exhibited significant hypoglycemic effects in normal and alloxan-induced hyperglycemic mice.
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Konno et al. (1985) studied this question.
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