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The possibility that diabetes mellitus, a common condition in many popula-tions, may increase the risk of hepato-cellular carcinoma (HCC) has been raised in a number of cohort and case– control studies (1–12). In particular, this hypothesis received strong support from two large population-based cohort stud-ies, one undertaken in Sweden (13) and the other in Denmark (14). Although most of the studies were methodologi-cally adequate, few directly adjusted for tobacco smoking and alcohol intake; moreover, in none, to our knowledge, were the results specifically controlled
Παγώνα Λάγιου (2000) studied this question.