Key result
An induction dose of enibomal increased the PEP/LVET-ratio by 8 to 60% and decreased 1/PEP^2 by 3 to 50%, indicating a reduction of myocardial contractility.
Why the study?
Does an induction dose of enibomal reduce myocardial contractility in surgical patients without heart disease?
Observational (n=16)
Does an induction dose of enibomal reduce myocardial contractility in surgical patients without heart disease?
An induction dose of enibomal reduces myocardial contractility, as evidenced by changes in systolic time intervals.
Answers are grounded in this paper and cite their sources.
Enibomal induction may reduce contractility in patients without heart disease; leaves open clinical relevance and requires randomized confirmation.
The systolic time intervals were studied in 16 surgical patients without heart disease between 29 and 75 years of age by a non‐invasive technique before and after an induction dose of enibomal (Narcodorm®). The pre‐injection period/left ventricular ejection time‐ratio (PEP/LVET‐ratio) increased between 8 and 60% and (1/PEP 2 ) decreased between 3 and 50%, indicating a reduction of myocardial contractility under the influence of enibomal. Factors responsible for circulatory depression during barbiturate anaesthesia are discussed. ZUSAMMENFASSUNG Mit Hilfe einer nicht‐invasiven Methode wurder bei 16 herzgesunden chirurgischen Patenten im Alter zwischen 29 und 75 Jahren die Systolen‐Intervalle vor und nach einer Einleitungsdosis von Enibomal (Narcodorm™) untersucht. Das PEP/LVET‐Verhältnis erhöhte sich um 8 bis 60% und 1/PEP 2 fiel um 3 bis50%, was auf eine Verminderung der Kontraktilität des Herzmuskels unter dem Einfluß von Enibomal hinweist. Die Faktoren, die für eine Kreislafudepression während Narkosen mit Barbituraten verantwortlich sind, werden diskutiert.
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Ibler et al. (1975) conducted an observational in Surgical patients without heart disease (n=16). Enibomal vs. Baseline (before injection) was evaluated on Systolic time intervals (PEP/LVET-ratio and 1/PEP^2) (PEP/LVET-ratio increased 8-60%; 1/PEP^2 decreased 3-50%). An induction dose of enibomal increased the PEP/LVET-ratio by 8 to 60% and decreased 1/PEP^2 by 3 to 50%, indicating a reduction of myocardial contractility.
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