Why the study?
Almost all combined oral contraceptives are associated with a risk of venous thrombosis regardless of drug composition and duration of therapy, warranting a review of pathogenetic mechanisms.
What are the pathogenetic mechanisms of thrombosis development during combined oral contraceptive use?
Design
Review
Key result
Combined oral contraceptives increase the risk of venous thrombosis through multiple pathogenetic mechanisms, including altered clotting factors and endothelial activation.
Authors
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Supports thrombosis risk assessment before COC use; leaves open dominant mechanisms for targeted validation.
What are the pathogenetic mechanisms of thrombosis development during combined oral contraceptive use?
Clinicians must carefully evaluate individual risk factors for thrombosis when prescribing combined oral contraceptives due to their multiple pro-thrombotic mechanisms.
Khizroeva et al. (2025) conducted a review in Venous thrombosis. Combined oral contraceptives was evaluated. Combined oral contraceptives increase the risk of venous thrombosis through multiple pathogenetic mechanisms, including altered clotting factors and endothelial activation.