Treatment of albino rats with a benzene extract of Ocimum sanctum leaves (250 mg/kg body weight) for 48 d decreased total sperm count, sperm motility, and forward velocity. The percentage of abnormal sperm increased in caudal epididymal fluid, and the fructose content decreased in the caudal plasma of the epididymis and the seminal vesicles. The results suggest that such effects are due to androgen deprivation, caused by the anti-androgenic property of O. sanctum leaves. The effect was reversible because all parameters returned to normal 2 wk after the withdrawal of treatment.
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Ahmed et al. (2002) studied this question.
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