April 1, 1991Current Opinion in Lipidology180 citations
View Full PaperThe low-density lipoprotein receptor-related protein: double agent or decoy?
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Abstract
The low-density lipoprotein receptor-related protein, a large cell-surface molecule with a multidomain structure, apparently serves a dual function, acting as a clearance receptor for two ligands that undergo activation during circulation in plasma. Chylomicron remnants (activated by apolipoprotein E enrichment) and α2-macroglobulin (activated by serum proteases) both bind avidly to this novel molecule.