Key points are not available for this paper at this time.
"... native collagen is unaffected by enzymes of mammalian origin acting within the pH range that exists in connective tissue..."1THIS comment, written in 1959 in a review of the structure and stability of collagen, was an accurate assessment of the biomedical literature at that time. However, multiple biologic and pathologic situations — ranging from remodeling of long bones during growth,2 resorption of the uterus after parturition3,4 to the rapid development of trophic ulcers of the skin in paralyzed patients5 and destruction of joints in rheumatoid arthritis6 — suggested that there were indeed enzymatic mechanisms for destruction of collagen.Then, . . .
Harris et al. (Thu,) studied this question.