Key result
Pregnancy in women with pulmonary arterial hypertension carried a high maternal mortality rate of 37.1%, mostly cumulating within the first month of delivery, with no fetal mortality observed.
Why the study?
Although pregnancy in women with pulmonary arterial hypertension is considered high risk, current data regarding pregnancy with pulmonary arterial hypertension are scarce.
What are the maternal and fetal outcomes and mortality risks for pregnant women with pulmonary arterial hypertension?
Observational (n=35)
No
What are the maternal and fetal outcomes and mortality risks for pregnant women with pulmonary arterial hypertension?
Pregnancy in women with pulmonary arterial hypertension carries a very high maternal mortality risk (37.1%), primarily in the early post-partum period, highlighting the need for proactive, multi-disciplinary management.
PAH pregnancies carry high maternal mortality warranting caution in counseling; leaves open optimal risk-reduction strategies.
BACKGROUND: Although pregnancy in women with pulmonary arterial hypertension has been considered a high-risk condition, current data regarding pregnancy with pulmonary arterial hypertension are scarce. In this study, we aimed to evaluate our single-center data on maternal and fetal outcomes in pregnant women with PAH and review currently available risk-based management strategies. METHODS: Our single-center study group comprised 35 women who became pregnant after the diagnosis of pulmonary arterial hypertension or in whom pulmonary arterial hypertension was diagnosed within early post-partum period. Clinical, laboratory, echocardiographic, and hemodynamic characteristics of pregnant and non-pregnant productive women with pulmonary arterial hypertension were compared, and similar comparison was also repeated for survivors and non-survivors in pregnant patient group. RESULTS: Pregnancy was noted in 15% of the 228 females with pulmonary arterial hypertension who were of hormonally productive ages, generally well-tolerated until delivery. Elective abortion and pre-term delivery were documented in 1 (2.8%) and 12 (35.3%) pregnant women, respectively. Switching to sildenafil was the standard medication during pregnancy. Cesarian section was the preferred method of delivery in all pregnant women with pulmonary arterial hypertension and was performed without any complication. Clinic deteoriation within the first week of delivery was observed in 5 (41.6%) patients. Maternal mortality was noted in 13 (37.1%) patients and was documented to cumulate within the first month of delivery. However, any sign predicting post-partum clinical deterioration was not found. No fetal mortality was observed. CONCLUSION: Despite the development of advanced therapies, pregnancy in pulmonary arterial hypertension still carries a high mortality risk and requires multi-disciplinary expert center care with more proactive management strategies.
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Tokgöz et al. (2022) conducted an observational in Pulmonary Arterial Hypertension in Pregnancy (n=35). Pregnancy vs. Non-pregnant women with pulmonary arterial hypertension was evaluated on Maternal mortality. Pregnancy in women with pulmonary arterial hypertension carried a high maternal mortality rate of 37.1%, mostly cumulating within the first month of delivery, with no fetal mortality observed.
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