Key result
The renin-angiotensin system is hypothesized to regulate blood vessel formation during normal development and cancer, based on a review of biochemical, genetic, clinical, and epidemiologic data.
Why the study?
Does the renin-angiotensin system participate in the regulation of human vasculogenesis and angiogenesis?
This paper proposes a novel hypothesis that the renin-angiotensin system plays a fundamental role in angiogenesis and vasculogenesis, which could have broad implications for cardiology, oncology, and neonatology.
Answers are grounded in this paper and cite their sources.
No immediate practice change in oncology or cardiology; leaves open RAS regulation of vasculogenesis for prospective validation.
Several lines of evidence suggest that hypertension and angiogenesis may be related phenomena but a functional link remains elusive. Here, we propose that the renin-angiotensin system (RAS), in addition to its central role in arterial hypertension, also regulates blood vessel formation during normal development and cancer. This mechanistic hypothesis is based on reports of biochemical, genetic, clinical, and epidemiologic data reviewed herein. Species differences between the RAS of rodents and humans likely account for why such a fundamental role in angiogenesis went unrecognized for so long. If proven correct, this hypothesis carries many implications for the medical practices of cardiology, oncology, and neonatology.
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Khakoo et al. (2008) conducted a review in Hypertension and angiogenesis. Renin-angiotensin system (RAS) was evaluated. The renin-angiotensin system is hypothesized to regulate blood vessel formation during normal development and cancer, based on a review of biochemical, genetic, clinical, and epidemiologic data.
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