Key result
Thallium-201 scintigraphy detected infarction in 93.8% of patients studied within 24 hours of symptom onset compared to 72.1% of those studied later (p<0.01).
Why the study?
Does the timing of Thallium-201 scintigraphy affect its diagnostic usefulness in patients with acute myocardial infarction?
Observational (n=200)
Does the timing of Thallium-201 scintigraphy affect its diagnostic usefulness in patients with acute myocardial infarction?
Absolute Event Rate: 93.75% vs 72.12%
p-value: p=<0.01
Thallium-201 scintigraphy is highly sensitive for detecting acute myocardial infarction, particularly when performed within the first 24 hours of symptom onset.
Early timing was associated with higher thallium-201 detection in acute MI; hypothesis-generating and should not yet change practice.
We examined the diagnostic usefulness of thallium-201 scintigraphy in 200 patients with acute myocardial infarction. The scintiscans showed a defect, suggesting infarction in 165. In all 44 patients studied iwthin six hours after onset of symptoms the scintiscans indicated a defect. Frequency of positive scans was significantly higher (90 of 96) in patients studied within 24 hours after onset than in those (75 of 104) studied later (p less than 0.01).
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Wackers et al. (1976) conducted an observational in Acute myocardial infarction (n=200). Thallium-201 scintigraphy within 24 hours of symptom onset vs. Thallium-201 scintigraphy later than 24 hours was evaluated on Positive scan (defect suggesting infarction) (p=<0.01). Thallium-201 scintigraphy detected infarction in 93.8% of patients studied within 24 hours of symptom onset compared to 72.1% of those studied later (p<0.01).
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