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This research investigates the functionality of cell-surface receptors for two retroviruses regarding phosphate transport.

Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters.

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This research investigates the functionality of cell-surface receptors for two retroviruses regarding phosphate transport.
Expression of Glvr-1 and Ram-1 in Xenopus laevis oocytes and mammalian cells.
Two-electrode voltage-clamp analysis to measure cation influx.
RNA analysis for tissue distribution of Glvr-1 and Ram-1.
Phosphate uptake was reduced by over 50% in mouse fibroblasts with amphotropic envelope glycoprotein.
Glvr-1 expression peaked in bone marrow, while Ram-1 was highest in heart tissue.
Depleting extracellular phosphate increased transporter expression by 3- to 5-fold.

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Randomized trial identifies phosphate symporter roles in specific tissues, suggesting therapeutic potential for gene modulation.

Kavanaugh et al. (1994) studied this question.

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