Key result
A newly developed mathematical model successfully reproduced steady-state force-calcium relationships, contraction force time courses, and frequency dependence in mouse ventricular myocytes.
Population
Mathematical model of mouse ventricular myocyte contraction at room temperature
Comparison
Electromechanical modeling incorporating… vs Experimental data and models using constant…
Design
Preclinical
Authors
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Should not yet influence clinical decisions; leaves open validation in human myocytes.
The developed mathematical model accurately simulates mouse ventricular myocyte contraction, highlighting the importance of incorporating variable sarcomere length to reproduce experimental force and shortening dynamics.
Mullins et al. (2013) studied Mouse ventricular myocyte contraction. Mathematical model of mouse ventricular myocyte contraction vs. Experimental data was evaluated on Model accuracy in reproducing experimental data on myocyte contraction. A newly developed mathematical model successfully reproduced steady-state force-calcium relationships, contraction force time courses, and frequency dependence in mouse ventricular myocytes.
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