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December 15, 2004Cardiovascular Research

Egr-1 negatively regulates expression of the sodium?calcium exchanger-1 in cardiomyocytes in vitro and in vivo

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Key result

Egr-1 negatively regulates NCX1 expression in cardiomyocytes, with Egr-1 overexpression reducing NCX1 protein to 30% of normal levels, suggesting a mechanism for its cardiac-sparing effects.

Population

Egr-1-deficient mice, wild-type mice, transgenic mice overexpressing Egr-1 in heart, and cardiac…

Comparison

Egr-1 deficiency, Egr-1 overexpression, and… vs Wild-type controls and naive controls

Design

Preclinical

Authors

CWChunhui WangManagement and Science UniversitySDStevan DostanicJewish General HospitalNSNicolas ServantInserm

Discussion

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Implication

Hypothesis-generating for Egr-1-targeted therapies in catecholamine cardiomyopathy; leaves open translation beyond animal models.

Structured PICO

P
Population
Egr-1-deficient (-/-) mice, wild-type (+/+) mice, transgenic mice overexpressing Egr-1 in heart, and cardiac differentiated H9c2 cells
I
Intervention
Egr-1 deficiency, Egr-1 overexpression, and catecholamine stimulation
C
Comparator
Wild-type controls and naive (unstimulated) controls
O
Outcome
Sodium calcium exchanger-1 (NCX1) expressionsurrogate

Egr-1 negatively regulates NCX1 expression in cardiomyocytes, suggesting a mechanism for its protective role against catecholamine-induced cardiac damage.

Cite This Study

Wang et al. (2004) studied Catecholamine-induced cardiac damage. Egr-1 expression vs. Wild-type or Egr-1 deficient models was evaluated on NCX1 expression. Egr-1 negatively regulates NCX1 expression in cardiomyocytes, with Egr-1 overexpression reducing NCX1 protein to 30% of normal levels, suggesting a mechanism for its cardiac-sparing effects.

synapsesocial.com/papers/6a223e932e2a416fdaa41cc2https://doi.org/10.1016/j.cardiores.2004.09.026
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Overexpression of the Cardiac Na + /Ca 2+ Exchanger Increases Susceptibility to Ischemia/Reperfusion Injury in Male, but Not Female, Transgenic Mice1998 · 192 citations
  2. 2Alpha 1-adrenergic stimulation of isolated rat atria results in discoordinate increases in natriuretic peptide secretion and gene expression and enhances Egr-1 and c-Myc expression.1996 · 41 citations
  3. 3Contractile Reserve and Intracellular Calcium Regulation in Mouse Myocytes From Normal and Hypertrophied Failing Hearts2000 · 93 citations
  4. 4Altered molecular response to adrenoreceptor-induced cardiac hypertrophy in Egr-1-deficient mice2000 · 63 citations
  5. 5Gender Influences [Ca2+]iDuring Metabolic Inhibition in Myocytes Overexpressing the Na+-Ca2+Exchanger2001 · 72 citations