Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 1, 1996Endocrinology

Alpha 1-adrenergic stimulation of isolated rat atria results in discoordinate increases in natriuretic peptide secretion and gene expression and enhances Egr-1 and c-Myc expression.

View Full Paper
Ask AI
Bookmark
Share

Population

Isolated right atria from rats

Comparison

Alpha1-adrenergic agonist phenylephrine at 10… vs Control (untreated)

Design

Preclinical

Follow-up

up to 8 hours

Authors

BBBenoit G. BruneauLPLeonardo A. Piazza

Discussion

Loading...

Member takes

Overview

Hypothesis-generating in rat atria; leaves open whether alpha1-adrenergic discoordination of ANF/BNP applies to human disease.

Structured PICO

P
Population
Isolated right atria from rats
I
Intervention
Alpha1-adrenergic agonist phenylephrine (PE) at 10, 50, or 100 microM for up to 8 hours
C
Comparator
Control (untreated)
O
Outcome
Secretion of immunoreactive atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP), and steady state transcript levels (mRNA) for ANF, BNP, Egr-1, and c-mycsurrogate

Alpha1-adrenergic stimulation of isolated rat atria increases ANF and BNP secretion and gene expression in a discoordinate manner, suggesting a mechanism for long-term natriuretic peptide production in cardiovascular disease.

Cite This Study

Bruneau et al. (1996) studied this question.

synapsesocial.com/papers/6a8bfacf95f0361a9ebef403https://doi.org/10.1210/endo.137.1.8536605
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Brain natriuretic peptide is induced by alpha 1-adrenergic agonists as a primary response gene in cultured rat cardiac myocytes1994 · 97 citations
  2. 2Selective changes in natriuretic peptide and early response gene expression in isolated rat atria following stimulation by stretch or endothelin-11994 · 79 citations
  3. 3Atrial stretch induces rapid increase in brain natriuretic peptide but not in atrial natriuretic peptide gene expression in vitro.1993 · 120 citations
  4. 4The alpha 1A-adrenergic receptor subtype mediates biochemical, molecular, and morphologic features of cultured myocardial cell hypertrophy1993 · 301 citations
  5. 5Role of calcium and protein kinase C in ANP secretion by cultured rat cardiocytes1988 · 57 citations