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October 1, 1994Cardiovascular Research

Selective changes in natriuretic peptide and early response gene expression in isolated rat atria following stimulation by stretch or endothelin-1

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Why the study?

Does mechanical stretch or endothelin-1 stimulate natriuretic peptide secretion and early response gene expression in isolated rat atria?

Population

Isolated adult rat atria

Comparison

Mechanical stretch or endothelin-1 (10 M) for 30… vs Basal levels (unstimulated)

Design

Preclinical

Follow-up

Up to 4 hours

Authors

BBBenoit G. Bruneau

Discussion

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Overview

Rat atrial data do not guide therapy; leaves open whether stretch and endothelin-1 pathways translate to human atrial disease.

Structured PICO

Does mechanical stretch or endothelin-1 stimulate natriuretic peptide secretion and early response gene expression in isolated rat atria?

P
Population
Isolated adult rat atria
I
Intervention
Mechanical stretch (5 g) or endothelin-1 (10(-7) M) for 30 min, 2 h, or 4 h
C
Comparator
Basal levels (unstimulated)
O
Outcome
ANF and BNP secretion (measured by radioimmunoassay) and relative mRNA levels (determined by northern blotting)surrogate

Mechanical stretch and endothelin-1 modulate atrial gene expression and natriuretic peptide secretion through distinct mechanisms in isolated rat atria.

Cite This Study

Benoit G. Bruneau (1994) studied this question.

synapsesocial.com/papers/6a85320522ea7ab258b2eae2https://doi.org/10.1093/cvr/28.10.1519
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1BNP gene expression is specifically modulated by stretch and ET-1 in a new model of isolated rat atria1997 · 109 citations
  2. 2Atrial stretch induces rapid increase in brain natriuretic peptide but not in atrial natriuretic peptide gene expression in vitro.1993 · 120 citations
  3. 3Endothelin-1 Is Involved in Stretch-Induced Early Activation of B-Type Natriuretic Peptide Gene Expression in Atrial but Not in Ventricular Myocytes1997 · 77 citations
  4. 4Interaction between stretch and hormonally stimulated atrial natriuretic peptide secretion1992 · 32 citations
  5. 5Alpha 1-adrenergic stimulation of isolated rat atria results in discoordinate increases in natriuretic peptide secretion and gene expression and enhances Egr-1 and c-Myc expression.1996 · 41 citations