Population
Isolated atrialectomized perfused hypertrophied hearts of 14- to 18-month-old spontaneously hypertensive…
Comparison
Graded passive myocardial stretch, with or… vs Basal state and age-matched normotensive…
Design
Preclinical
Authors
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Should not alter heart failure management; leaves open protein kinase C involvement in stretch-induced natriuretic peptide release from hypertrophied ventricles.
Myocardial stretch stimulates ANP and BNP secretion from hypertrophic ventricular myocytes, a process likely involving protein kinase-C but not extracellular calcium influx.
P. Kinnunen (1993) studied this question.
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