Key result
Elevation of left atrial filling pressure caused a pressure-dependent, reversible increase in ANP release that was inhibited by low calcium, nifedipine, W-7, or ryanodine.
Population
Isolated rat hearts perfused in Langendorff or working mode
Comparison
Mechanical stretch via elevation of left atrial… vs Baseline conditions
Design
Preclinical
Authors
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Hypothesis-generating for calcium-dependent ANP regulation; leaves open translation to human atrial physiology or therapy.
ANP secretion in isolated rat hearts is primarily regulated by mechanical stretch of the atrial wall, a process dependent on calcium influx and intracellular calcium-calmodulin kinase activation.
Toyama et al. (1990) studied this question. Elevation of left atrial filling pressure vs. Baseline pressure was evaluated on ANP release. Elevation of left atrial filling pressure caused a pressure-dependent, reversible increase in ANP release that was inhibited by low calcium, nifedipine, W-7, or ryanodine.
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