Population
Isolated perfused rat hearts, neonatal cultured rat atrial myocytes, and severely hypertrophied ventricles…
Comparison
Phorbol esters, Ca2+ ionophore A23187, Ca2+… vs Basal conditions or normal rat myocardium
Design
Preclinical
Authors
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Hypothesis-generating for PKC in stretch-mediated ANF release from rodent myocardium; leaves open translation to human HF or hypertrophy therapies.
Protein kinase C activity plays an important role in regulating basal and stretch-induced ANF secretion from atrial and ventricular cells.
Ruskoaho et al. (1991) studied this question.
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