Population
7- to 8-day primary cultures of atrial myocytes from adult rats
Comparison
Pharmacological manipulation vs Control conditions
Design
Preclinical
Follow-up
2 hours
Authors
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May inform ANP regulation in atrial models; leaves open translation to human disease or in vivo function.
In cultured adult rat atrial myocytes, ANP secretion can occur and be stimulated by TPA independently of transplasmalemmal Ca2+ influx or ryanodine-inhibitable SR Ca2+ release when contractions are absent.
Iida et al. (1989) studied this question.
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