Key result
The phorbol ester TPA significantly increased ANP release from the hypertrophied ventricles of old spontaneously hypertensive rats (from 413 to 623 pg/ml, P<0.001).
Population
Isolated, perfused heart preparations from 2- and 21-month-old Wistar-Kyoto and spontaneously hypertensive…
Comparison
12-O-tetradecanoyl-phorbol-13-acetate added to… vs Control hearts and normal ventricular tissue
Design
Preclinical
Follow-up
30 min
Authors
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Supports regulated ANP secretion via PKC in hypertrophied ventricles; leaves open human relevance and therapeutic translation.
Absolute Event Rate: 623% vs 413%
p-value: p=<0.001
Hypertrophied rat ventricular myocytes possess the cellular mechanisms to secrete ANP via a regulated pathway involving protein kinase C.
Kinnunen et al. (1991) studied Ventricular hypertrophy. 12-O-tetradecanoyl-phorbol-13-acetate (TPA) vs. Control hearts / WKY rats was evaluated on ANP release from hypertrophied ventricles (p=<0.001). The phorbol ester TPA significantly increased ANP release from the hypertrophied ventricles of old spontaneously hypertensive rats (from 413 to 623 pg/ml, P<0.001).
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