Key result
Minoxidil treatment for 8 weeks induced ventricular hypertrophy and significantly increased plasma IR-ANP concentrations in both WKY (from 133 to 281 pg/ml, P<0.01) and SHR rats (from 184 to 339 pg/ml, P<0.05).
Population
12-month-old Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats
Comparison
Minoxidil treatment for 8 weeks vs Untreated age-matched control WKY and SHR rats
Design
Preclinical
Follow-up
8 weeks
Authors
Loading...
Minoxidil-induced hypertrophy may elevate circulating ANP via ventricular secretion in rats; leaves open its role in human heart disease.
p-value: p=<0.01
Ventricular hypertrophy induced by minoxidil in rats significantly increases the ventricular synthesis and secretion of atrial natriuretic peptide into the circulation.
Kinnunen et al. (1990) studied Ventricular hypertrophy (n=26). Minoxidil vs. Untreated control rats was evaluated on Plasma IR-ANP concentrations (p=<0.01). Minoxidil treatment for 8 weeks induced ventricular hypertrophy and significantly increased plasma IR-ANP concentrations in both WKY (from 133 to 281 pg/ml, P<0.01) and SHR rats (from 184 to 339 pg/ml, P<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: