What does this research mean for the field?

Aging in normotensive rats is associated with a marked increase in left ventricular ANP gene expression and peptide concentrations that correlates with cardiac hypertrophy. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

September 1, 1995AJP Heart and Circulatory Physiology

Age-associated increase in rat ventricular ANP gene expression correlates with cardiac hypertrophy

Q: What are the key findings of this study?

Aging to 22-24 months in rats was associated with a sevenfold increase in left ventricular ANP mRNA (P<0.05) and a four- to fivefold increase in ANP peptide concentration compared to 6-month-old rats.

Q: What is the clinical evidence from this study?

Study design: Other. Population: Cardiac hypertrophy and aging. Intervention: Aging (18 to 24 months) vs. 6-month-old rats. Primary outcome: Left ventricular ANP mRNA levels and ANP peptide concentrations (p=< 0.05).

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Key result

Aging in rats is linked to a ~7-fold increase in left ventricular ANP mRNA.

P<0.05

Authors

AYAména Ben YounesZiguinchor University MBMarvin O. BoluytWashtenaw Community College LOL O'NeillOregon Health & Science University

Discussion

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Implication

May reflect compensatory mechanisms in aged rodent hearts; extends animal data on ANP but leaves open clinical translation.

PICO

Population

Rats aged 2, 6, 18, and 22-24 months evaluated for age-associated changes in ANP gene expression and cardiac hypertrophy.

Exposure / Comparator

Aging (18 to 24 months) vs 6-month-old rats

Primary Outcome

Left ventricular ANP mRNA levels and ANP peptide concentrations, p=< 0.05

Main Result

p-value: p=< 0.05

Cite This Study

Younes et al. (1995) studied Cardiac hypertrophy and aging. Aging (18 to 24 months) vs. 6-month-old rats was evaluated on Left ventricular ANP mRNA levels and ANP peptide concentrations (p=< 0.05). Aging to 22-24 months in rats was associated with a sevenfold increase in left ventricular ANP mRNA (P<0.05) and a four- to fivefold increase in ANP peptide concentration compared to 6-month-old rats.

synapsesocial.com/papers/6aa7defbdafa71edbfae5b5e https://doi.org/10.1152/ajpheart.1995.269.3.h1003

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Age-associated increase in rat ventricular ANP gene expression correlates with cardiac hypertrophy

Discussion

Member takes

Implication

PICO

Main Result

Cite This Study

Age-associated increase in rat ventricular ANP gene expression correlates with cardiac hypertrophy

Discussion

Member takes

Implication

PICO

Main Result

Cite This Study

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