Key result
Plasma and ventricular atrial natriuretic peptide levels increase with age and heart failure as a compensatory mechanism to regulate blood pressure and volume homeostasis.
Why the study?
Aging is a major risk factor for hypertension and may activate compensatory mechanisms affecting ANP levels in plasma and tissues, but its influence on ANP distribution is not fully understood.
Should not alter ANP assessment in older patients; leaves open translation of compensatory ventricular changes to human aging or HF.
Atrial natriuretic peptide (ANP) is a hormone important in the cardiovascular system via its regulatory roles in sodium and water excretion, and in vasodilatation. Aging represents a major risk factor in the development of hypertension, a perturbation which may activate compensatory mechanisms. The influence of aging on the ANP levels in plasma, atria, ventricles, hypothalamus, and brainstem was evaluated by comparing young (3 mo), middle-aged (12 mo), and old (24 mo) rats. Plasma and ventricular ANP levels increased with age, while ANP content in the atria as well as hypothalamus decreased significantly. PreproANP mRNA contents increased with age in the ventricle but not in the atrium. It is suggested that the increase in plasma ANP levels in old rats is due to the increase in ANP secretion from the atrium and the ventricle, partly as a result of an increase of release of ANP from hypothalamus.
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Kwan et al. (1997) conducted a review in Heart failure and cardiovascular diseases. Atrial natriuretic peptide (ANP) was evaluated. Plasma and ventricular atrial natriuretic peptide levels increase with age and heart failure as a compensatory mechanism to regulate blood pressure and volume homeostasis.
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