Key result
Plasma ANP is ~3.4-fold higher in elderly patients with heart disease and rises with age.
Why the study?
The clinical significance of plasma immunoreactive atrial natriuretic peptide (ANP) levels in elderly patients with or without heart diseases was unclear.
Are plasma ANP levels elevated in elderly patients with heart diseases compared to those without, and do they increase with age?
Observational (n=79)
Are plasma ANP levels elevated in elderly patients with heart diseases compared to those without, and do they increase with age?
Absolute Event Rate: 158.4% vs 46%
p-value: p=<0.05
Plasma ANP levels increase with age and are significantly elevated in elderly patients with heart diseases, particularly congestive heart failure and atrial fibrillation.
Authors
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Elevated ANP may signal heart disease in older adults but requires age adjustment; leaves open prospective validation for clinical adoption.
Ezaki et al. (1988) conducted an observational in Heart diseases (n=79). Heart diseases vs. No heart diseases was evaluated on Plasma levels of immunoreactive atrial natriuretic peptide (ANP) (p=<0.05). Plasma ANP levels were significantly higher in elderly patients with heart diseases compared to those without (158.4 vs 46.0 pg/mL; P<0.05), and increased with advancing age.
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