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December 1, 1997AJP Heart and Circulatory Physiology

BNP gene expression is specifically modulated by stretch and ET-1 in a new model of isolated rat atria

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Population

Isolated right atria from the rat

Design

Preclinical

Follow-up

8 hours

Authors

BBBenoit G. BruneauGladstone InstitutesLPLeonardo A. PiazzaUniversity of Buenos Aires

Discussion

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Implication

Does not support clinical BNP modulation changes; leaves open independent ANF/BNP regulation in human hemodynamic stress.

Structured PICO

P
Population
Isolated right atria from the rat
I
Intervention
Stretch or endothelin-1 (ET-1)
O
Outcome
Atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP) secretion and gene expressionsurrogate

Stretch and ET-1 specifically modulate BNP gene expression in isolated rat atria, suggesting independent regulation of ANF and BNP synthesis in response to hemodynamic or neuroendocrine stress.

Cite This Study

Bruneau et al. (1997) studied this question.

synapsesocial.com/papers/6a7c9e2874c8907ce7a8affchttps://doi.org/10.1152/ajpheart.1997.273.6.h2678
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mechanical and neuroendocrine regulation of the endocrine heart1996 · 321 citations
  2. 2Endothelin acts as a paracrine regulator of stretch-induced atrial natriuretic peptide release1995 · 39 citations
  3. 3Rat brain natriuretic peptide is localized in atrial granules and released into the circulation1992 · 54 citations
  4. 4Stretch-dependent regulation of atrial peptide synthesis and secretion in cultured atrial cardiocytes1992 · 34 citations
  5. 5Load responsiveness of protein synthesis in adult mammalian myocardium: role of cardiac deformation linked to sodium influx.1989 · 151 citations