Population
Stable isolated rat atrial preparation (adult atrial muscle)
Comparison
Mechanical, hormonal, and alpha1-adrenergic… vs Basal conditions
Design
Preclinical
Authors
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Constitutive-like secretion may predominate in atrial ANF/BNP release; leaves open relevance to human cardiac disease or therapy.
In adult atrial cardiocytes, basal and stimulated ANF and BNP secretion have a large constitutive-like component, depending more on the formation rate of immature granules than on stored hormone amounts.
Ogawa et al. (1999) studied this question.
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