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February 27, 2020Balkan Medical JournalOpen Access

R-(-)-carvone Attenuated Doxorubicin Induced Cardiotoxicity In Vivo and Potentiated Its Anticancer Toxicity In Vitro

Manal Abbas Yasser I. Kandil Manal A. Abbas

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Abstract

Background: Doxorubicin is one of the most potent broad-spectrum antitumor and chemotherapeutic agents. However, it produces cardiotoxicity. Aims: . Study Design: Cell culture and animal experiment. Methods: . Furthermore, the mechanism of its cardioprotective effect was studied. Results: was due to an increase in catalase activity. Conclusion: R-(-)-carvone has synergistic anticancer action with doxorubicin on the MCF 7 cell line while decreasing its cardiotoxicity.

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Abbas et al. (2020) studied this question.

synapsesocial.com/papers/6a223e99c7675eb2859713e7 https://doi.org/10.4274/balkanmedj.galenos.2019.2019.7.117

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