Key result
MrgD-positive cells are expressed in a region-specific manner in the adult mouse forebrain, including cortical, limbic, and basal ganglia areas.
Why the study?
The biological and physiological relevance of MrgD interaction remains obscure, and recent studies hinted at a role of MrgD in the central nervous system.
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Maps MrgD in adult mouse forebrain circuits; leaves open functional and translational roles in cardiovascular research.
-(Ang-(1-7), also named alamandine, and Ang-(1-7). However, the biological and physiological relevance of this interaction remains obscure. Since several recent studies hinted at a role of MrgD in the CNS, we determined the distribution pattern of MrgD receptors in the adult mouse brain by using a genetic mouse model with tracers of MrgD expression. MrgD-positive cells could be identified in some forebrain areas, including cortex, hippocampus, amygdala, hypothalamus, habenular nuclei, striatum and pallidum, as well as in some mid-brain nuclei in a region-specific manner. The specific localization of MrgD in the reward- and limbic-related areas can hint at a role of MrgD in processes such as pain perception/modulation, synaptic plasticity, learning, memory and cognition.
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Hami et al. (2021) studied this question. MrgD expression mapping vs. Control mice was evaluated on Localization and expression of MrgD-positive cells in the mouse brain. MrgD-positive cells are expressed in a region-specific manner in the adult mouse forebrain, including cortical, limbic, and basal ganglia areas.
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