Key result
Untreated mild-to-moderate hypertension was not associated with increased urinary 15-F(2t)-IsoP levels compared with healthy controls (69 vs 75 pmol/mmol creatinine; 95% CI difference -23 to 13).
Why the study?
Are urinary levels of 15-F(2t)-IsoP (a marker of lipid peroxidation) increased in patients with never-treated mild-to-moderate hypertension compared to healthy controls?
Population
60 subjects: 30 patients with never-treated mild-to-moderate essential hypertension and 30 gender- and…
Design
Case-control
Authors
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Suggests oxidative stress may not initiate mild hypertension; leaves open its role in progression or target-organ damage.
Case-Control (n=60)
Are urinary levels of 15-F(2t)-IsoP (a marker of lipid peroxidation) increased in patients with never-treated mild-to-moderate hypertension compared to healthy controls?
Absolute Event Rate: 69% vs 75%
Lipid peroxidation, as measured by urinary 15-F(2t)-IsoP, is not increased in early-stage, untreated mild-to-moderate essential hypertension, suggesting oxidative stress may not drive its early pathogenesis.
Cracowski et al. (2003) conducted a case-control in Mild-to-moderate hypertension (n=60). Untreated mild-to-moderate hypertension vs. Gender- and age-paired healthy controls was evaluated on Urinary 15-F(2t)-IsoP levels (95% CI -23 to 13). Untreated mild-to-moderate hypertension was not associated with increased urinary 15-F(2t)-IsoP levels compared with healthy controls (69 vs 75 pmol/mmol creatinine; 95% CI difference -23 to 13).
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