This study provides a theoretical and kinematical model explaining the mechanism by which antitachycardia pacing unpins spiral waves, consistent with numerical simulations.
Hypothesis-generating for antitachycardia pacing mechanisms in spiral reentry; leaves open clinical validation.
Antitachycardia pacing (ATP) is widely used to terminate tachycardia before it proceeds to lethal fibrillation. The important prerequisite for successful ATP is unpinning of the spirals anchored to the obstacle by a series of stimuli. Here, to understand the mechanism of unpinning spirals by ATP, we propose a theoretical explanation based on a nonlinear eikonal relation and a kinematical model. The theoretical results are quantitatively consistent with the numerical simulations in both weak and high excitabilities.
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Gao et al. (2014) studied this question.
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