Key result
In canine right atria during atrial fibrillation, the relationship between propagation direction and APD90 gradient was no different from uniformly random vectors.
Why the study?
Is propagation direction during atrial fibrillation consistently related to the gradient of 90% action potential duration in a canine model?
Is propagation direction during atrial fibrillation consistently related to the gradient of 90% action potential duration in a canine model?
This preclinical study demonstrates that while propagation direction during atrial fibrillation is not consistently related to APD90 gradient, the curl of propagation direction is higher at sites with large APD90 gradients.
Questions APD90 gradient role in AF propagation; hypothesis-generating for curl in canine models.
The authors hypothesized that propagation direction (PD) during atrial fibrillation (AF) is related consistently to gradient of 90% action potential duration (APD90). Monophasic action potentials (MAPs) were recorded at 250 sites from the endocardium of acetylcholine (ACh) perfused canine right atria during pacing. The APD90 field and its gradient were computed from MAP waveforms. Two-dimensional velocity vector fields were estimated from epicardial mapping data acquired during ACh mediated AF. Average PD vector fields were compared to vector fields of APD90 gradient. In 27 episodes of AF, the relationship between PD and APD90 gradient was no different from that of an equal number of uniformly random vectors. However, the curl of PD was higher at sites of large APD90 gradients. Methods were validated in 2-D simulations.
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Kay et al. (2002) studied Atrial fibrillation. Spatial dispersion of recovery (APD90 gradient) vs. Uniformly random vectors was evaluated on Relationship between propagation direction (PD) and APD90 gradient. In canine right atria during atrial fibrillation, the relationship between propagation direction and APD90 gradient was no different from uniformly random vectors.
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