Key result
Acetylcholine perfusion significantly altered the spatial mean, standard deviation, and mean gradient of APD90 in canine right atria compared to control conditions.
Why the study?
Does acetylcholine perfusion alter the spatial distribution of repolarization time in canine right atria?
Does acetylcholine perfusion alter the spatial distribution of repolarization time in canine right atria?
Acetylcholine significantly alters the spatial mean and gradient of repolarization time in canine right atria without increasing spatial randomness.
Acetylcholine modulates canine atrial repolarization gradients; hypothesis-generating for vagal effects on human AF substrates.
The spatial distribution of repolarization time in canine right atria was estimated from monophasic action potentials (MAPs) and characterized statistically. MAP waveforms were collected from 76 sites within the right atrium of 11 dogs under control conditions and with perfusion of 0.5 and 1.0 /spl mu/M acetylcholine (ACH) solutions. The 90% action potential duration (APD90) was estimated automatically from MAP waveforms. Spatial resolution was investigated in two preparations by comparing APD90 fields generated using 76 data points to APD90 fields generated using 250 data points. The spatial mean of APD90, spatial standard deviation of APD90, mean gradient, and standard deviation of gradient were all found to be significantly different between the control and ACH preparations. ACH did not appear to increase the spatial randomness of APD90, as measured by estimates of correlation length and the effective wavelength of the APD90 field.
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Kay et al. (2002) studied this question. Acetylcholine (ACH) vs. Control conditions was evaluated on Spatial mean, spatial standard deviation, mean gradient, and standard deviation of gradient of APD90. Acetylcholine perfusion significantly altered the spatial mean, standard deviation, and mean gradient of APD90 in canine right atria compared to control conditions.
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