Why the study?
AAA is usually asymptomatic with high mortality if rupture occurs, and few studies have evaluated pulse wave propagation with AAA to support pulse-wave-based detection.
Does abdominal aortic aneurysm morphology and stiffness alter pulse wave morphology in a computational model?
Does abdominal aortic aneurysm morphology and stiffness alter pulse wave morphology in a computational model?
Computational modeling demonstrates that AAA maximum diameter and arterial stiffness significantly alter pulse wave morphology, suggesting pulse wave analysis could be a potential tool for AAA detection.
May warrant pulse wave analysis exploration for AAA detection; hypothesis-generating from computational models and leaves open clinical translation.
Background Abdominal aortic aneurysm (AAA) is usually asymptomatic and has an extremely high mortality if rupture occurs. Therefore, early detection and intervention are important. However, AAA is most often detected as an accidental finding during clinical imaging for other purposes [1]. Considering that AAA has a systemic impact on the biophysical properties of the cardiovascular system, pulse-wave-based diagnosis of AAA may be a potential approach for effective detection. There have been only a few studies of pulse wave propagation with AAA by using computational modelling or hydraulic simulators [2]. This study aims to provide some basic insights for pulse-wave-based diagnosis of AAA using computational modelling. Methods We simulated blood flow in the larger systemic arteries using the 65-year-old baseline model from the pulse wave database in Charlton et al. [3] (see Figure, left). The influence on pulse waveforms of AAA morphology (including shape, maximum diameter and length) was simulated by adjusting the geometry of the abdominal aorta IV. In addition, the influence of the local AAA stiffness and global arterial stiffness (represented by carotid-femoral pulse wave velocity) was investigated by varying the relevant model parameters. Results Results show that maximum diameter is the dominant morphological factor in reshaping the pulse waveform, introducing considerable changes in pulse wave indices. Moreover, both local and global arterial stiffness have a considerable impact on wave morphology in the presence of AAA (Figure, right). Conclusion AAA produces considerable changes in pulse wave morphology that could be used for AAA detection by using pulse wave analysis.
No takes yet. Share an insight, caveat, or question.
Wang et al. (2020) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: