Antiepileptic drugs and suicide risk: could stopping medications pose a greater hazard?

. Drug companies had previously been asked to submit data from placebo-controlled tri-als of AEDs, regardless of indication, when at least 30 people were enrolled. A total of 11 compounds were involved in 199 placebo-controlled trials, with over 27,000 individuals taking AEDs and 16,000 on placebo. The overall odds ratio (OR) for spontaneously reported suicidal behavior or ideation in those taking active drugs was 1.8 (95% CI: 1.24–2.66)