Key result
Six weeks of aerobic training increased neuropilin-1 transcript abundance by 800% only in subjects who demonstrated a high physiological adaptation to exercise.
Why the study?
Does six weeks of high-intensity aerobic cycle training modulate extracellular matrix gene expression in sedentary males in correlation with physiological adaptation?
Observational (n=24)
No
Does six weeks of high-intensity aerobic cycle training modulate extracellular matrix gene expression in sedentary males in correlation with physiological adaptation?
p-value: p=<0.001
Aerobic exercise training activates specific extracellular matrix genes in human skeletal muscle only in individuals who demonstrate significant physiological adaptation (increased aerobic capacity).
No takes yet. Share an insight, caveat, or question.
Neuropilin-1 changes limited to high responders; hypothesis-generating and requires prospective confirmation before clinical use.
Timmons et al. (2005) conducted an observational in Sedentary (n=24). High-intensity aerobic cycle training vs. Low-responder group (LRG) was evaluated on Neuropilin-1 transcript abundance increase (p=<0.001). Six weeks of aerobic training increased neuropilin-1 transcript abundance by 800% only in subjects who demonstrated a high physiological adaptation to exercise.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: