Key result
Six weeks of aerobic training increased neuropilin-1 transcript abundance by 800% only in subjects who demonstrated a high physiological adaptation to exercise.
Why the study?
Does six weeks of high-intensity aerobic cycle training modulate extracellular matrix gene expression in sedentary males in correlation with physiological adaptation?
Population
24 sedentary male subjects. Two cohorts were analyzed: a high-responder group and a low-responder group…
Comparison
Six weeks of high-intensity aerobic cycle… vs Pre-training baseline and comparison between…
Design
Cohort
Follow-up
6 weeks
Authors
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Neuropilin-1 changes limited to high responders; hypothesis-generating and requires prospective confirmation before clinical use.
Observational (n=24)
No
Does six weeks of high-intensity aerobic cycle training modulate extracellular matrix gene expression in sedentary males in correlation with physiological adaptation?
p-value: p=<0.001
Aerobic exercise training activates specific extracellular matrix genes in human skeletal muscle only in individuals who demonstrate significant physiological adaptation (increased aerobic capacity).
Timmons et al. (2005) conducted an observational in Sedentary (n=24). High-intensity aerobic cycle training vs. Low-responder group (LRG) was evaluated on Neuropilin-1 transcript abundance increase (p=<0.001). Six weeks of aerobic training increased neuropilin-1 transcript abundance by 800% only in subjects who demonstrated a high physiological adaptation to exercise.
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