Key result
In transgenic mice with increased c-myc expression, myocardial growth induced by T3 was significantly greater than that induced by isoproterenol (P<0.001).
Why the study?
Does increased basal expression of the c-myc protooncogene modulate cardiac hypertrophic growth in response to pharmacological stimuli in mice?
Population
Transgenic mice exhibiting a 20-fold increase in cardiac c-myc expression and nontransgenic control mice
Comparison
Pharmacological stimulation of myocyte growth… vs Nontransgenic mice receiving the same stimuli…
Design
Preclinical
Authors
Loading...
No immediate clinical implications; leaves open c-myc as a modulator of stimulus-specific hypertrophy for further study.
Does increased basal expression of the c-myc protooncogene modulate cardiac hypertrophic growth in response to pharmacological stimuli in mice?
p-value: p=<0.001
Increasing basal c-myc expression in cardiac myocytes alters the in vivo hypertrophic growth response to specific stimuli, implicating c-myc in selective hypertrophic signal transduction.
Robbins et al. (1992) studied Cardiac hypertrophic growth. Triiodothyronine (T3) and isoproterenol vs. Nontransgenic mice was evaluated on Myocardial growth (p=<0.001). In transgenic mice with increased c-myc expression, myocardial growth induced by T3 was significantly greater than that induced by isoproterenol (P<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: