Key result
The inserted isoform [(+)insert] and the mutant lacking the insert [(-)insert] had similar unitary displacements (~10 nm), but the attachment time for the (-)insert was two times that of the (+)insert.
The seven amino acid insert in the nucleotide-binding loop of smooth muscle myosin affects the kinetics of the cross-bridge cycle rather than the inherent mechanics of the molecule.
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May refine cross-bridge models in smooth muscle; leaves open translation to human vascular disease.
LAUZON et al. (1998) studied this question. Inserted isoform [(+)insert] vs. Mutant lacking the insert [(-)insert] was evaluated on Unitary displacements (Duni) and attachment time (ton). The inserted isoform [(+)insert] and the mutant lacking the insert [(-)insert] had similar unitary displacements (~10 nm), but the attachment time for the (-)insert was two times that of the (+)insert.
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