Key result
ATPase activity in isometric rabbit muscle fibres during the first few turnovers is about an order of magnitude greater than that when a steady state is reached.
Population
Single permeabilized muscle fibres from rabbit psoas muscle and frog semitendinosus muscle
Comparison
Laser flash photolysis of NPE-caged ATP or… vs Presence vs absence of Ca2+, different…
Design
Preclinical
Authors
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May inform muscle energetics models; leaves open translation to human cardiac or skeletal function.
ATPase activity in isometric muscle fibres during initial turnovers is significantly higher than steady-state levels, providing insights into the mechanism of muscular contraction.
He et al. (1997) studied this question. Photolysis of NPE-caged ATP vs. Absence of Ca2+ / steady state was evaluated on ATPase activity (rate of appearance of inorganic phosphate). ATPase activity in isometric rabbit muscle fibres during the first few turnovers is about an order of magnitude greater than that when a steady state is reached.
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