Key result
Endothelial-to-mesenchymal transition is an essential process for heart valve development that persists in adult valves and may mediate both physiological adaptation and maladaptive disease responses.
EndMT is a fundamental cellular process crucial for heart valve development and potentially implicated in adult valvular disease and adaptation.
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EndMT may link developmental biology to adult valve pathology; leaves open its therapeutic targeting pending mechanistic studies.
Joyce Bischoff (2019) conducted a review in Endothelial-to-Mesenchymal Transition. Endothelial-to-mesenchymal transition is an essential process for heart valve development that persists in adult valves and may mediate both physiological adaptation and maladaptive disease responses.
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