Key result
A positron-sensitive probe detected 4.8-fold higher mean Z-scores (CI 3.4-6.3; P<0.001) over atherosclerotic injured iliac arteries compared with uninjured normal segments in a rabbit model.
Why the study?
Does a positron-sensitive probe with FDG distinguish atherosclerotic from healthy artery segments in a rabbit model?
Population
11 New Zealand White rabbits with Fogarty-catheter injury of an iliac artery fed a high-fat diet for 3 weeks
Comparison
18-fluorodeoxyglucose 90-180 MBq injection… vs Uninjured normal iliac artery segments within…
Design
Preclinical
Follow-up
3 weeks (diet), 2-4 hours post-injection
Authors
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Supports preclinical feasibility of intravascular FDG plaque detection; leaves open translation to human atherosclerosis imaging.
Does a positron-sensitive probe with FDG distinguish atherosclerotic from healthy artery segments in a rabbit model?
Effect estimate: 4.8-fold higher (95% CI 3.4-6.3)
p-value: p=<0.001
A novel positron-sensitive probe using FDG successfully distinguished atherosclerotic from healthy artery segments in a rabbit model, suggesting feasibility for intravascular study of plaque biology.
Lederman et al. (2001) studied Atherosclerosis (n=11). Positron-sensitive fiberoptic probe and 18-fluorodeoxyglucose (FDG) vs. Uninjured normal iliac artery segments was evaluated on Mean probe Z-scores (4.8-fold higher, 95% CI 3.4-6.3, p=<0.001). A positron-sensitive probe detected 4.8-fold higher mean Z-scores (CI 3.4-6.3; P<0.001) over atherosclerotic injured iliac arteries compared with uninjured normal segments in a rabbit model.
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