Key result
Iron overload in ventricular cardiomyocytes decreased the overshoot and duration of the cardiac action potential, reduced sodium current, and increased transient outward potassium current.
Why the study?
Does iron overload alter excitability and ion currents in cardiac myocytes?
Population
Mongolian gerbil model of human iron overload and neonatal rat cardiomyocytes
Design
Preclinical
Authors
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May explain arrhythmogenesis in siderotic cardiomyopathy; leaves open translation to human disease.
Does iron overload alter excitability and ion currents in cardiac myocytes?
Iron overload alters cardiac action potentials and ion currents, providing a potential mechanism for arrhythmogenesis in human siderotic heart disease.
Kuryshev et al. (1999) studied Iron overload / iron-induced cardiomyopathy. Iron overload (iron dextran injections / iron incubation) was evaluated on Action potential, sodium and potassium currents, and sodium channel protein. Iron overload in ventricular cardiomyocytes decreased the overshoot and duration of the cardiac action potential, reduced sodium current, and increased transient outward potassium current.
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