Key result
Low-pass filtering of simulated single channels with a single amplitude can produce an unexpected bimodal amplitude distribution, suggesting such distributions do not prove the existence of two channel types.
Population
Voltage-dependent membrane channels (calcium channels) and simulated single channels
Design
Preclinical
Authors
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Filtering artifacts may falsely suggest bimodal channel amplitudes; leaves open whether such distributions indicate distinct channel types without simulation checks.
Low-pass filtering of single-channel recordings can introduce significant artifacts, including falsely prolonged open/closed times and artificial bimodal amplitude distributions, which can be corrected using specific analytical methods.
Wilson et al. (1985) studied Calcium channels. Low-pass filtering was evaluated on Effects of low-pass filtering on WCO histograms. Low-pass filtering of simulated single channels with a single amplitude can produce an unexpected bimodal amplitude distribution, suggesting such distributions do not prove the existence of two channel types.
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