Key result
Among 23 patients with infective endocarditis, 9 died (6 in-hospital, 3 post-discharge), with higher mortality observed in cases with negative blood cultures, marked anemia, and low serum cholesterol.
Observational (n=23)
No
In this 11-year retrospective series, infective endocarditis carried a high mortality rate, particularly in patients with negative blood cultures and markers of severe systemic illness such as low serum iron and cholesterol.
Alerts to high mortality risk in culture-negative IE with anemia; leaves open validation of these markers in larger cohorts.
Clinical records of 23 cases of infective endocarditis admitted to our department during the last 11 years were reviewed. All had underlying heart disease : six had congenital heart disease and 17 had acquired valvular disease. The duration of the disease before the correct diagnosis was three months or longer in eight cases. Causative organisms were recovered in 16 patients (69.6%), while the blood culture was positive in 12 of 15 cases (80%) not receiving intravenous administration of antibiotics for at least seven days before admission. The most frequently recovered organism was streptococcus. viridans. Echocardiographic studies could reveal suggestive signs of the disease in 12 of 20 subjects. Congestive heart failure was a complication in 12 cases. Six patients died in the hospital, while three died after discharge. Of these, eight had acquired valvular disease. The mortality was high in the cases with negative blood culture. Marked anemia, low serum iron and low serum cholesterol also suggested a poor prognosis.
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NAGUMO et al. (1985) conducted an observational in Infective endocarditis (n=23). Infective endocarditis was evaluated on Mortality and clinical characteristics. Among 23 patients with infective endocarditis, 9 died (6 in-hospital, 3 post-discharge), with higher mortality observed in cases with negative blood cultures, marked anemia, and low serum cholesterol.
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