Key result
Specific genetic variants and non-coding RNAs regulate predisposition to and development of myocardial fibrosis.
Why the study?
Myocardial fibrosis is a multifactorial process influenced by genetically determined cellular and molecular factors that may inform research on assessing heart failure risk.
This review highlights genetic variants associated with myocardial fibrosis, offering potential avenues for assessing heart failure risk.
Answers are grounded in this paper and cite their sources.
May support future HF risk stratification; leaves open clinical utility pending prospective validation of genetic variants.
Myocardial fibrosis is a multifactorial process, which predisposes to a number of cellular and molecular factors, the level of which is determined genetically. This review discusses some genetic variants that are directly related to the development of cardiac fibrosis and open up prospects for scientific research on assessing the risk of heart failure in various cardiovascular pathologies.
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Гриценко et al. (2022) conducted a review in Myocardial fibrosis. Molecular genetic variants was evaluated. Multiple genetic variants, including non-coding RNAs, matrix metalloproteinases, tissue inhibitors, TGF-beta 1, and elastin, play a significant role in the predisposition and development of myocardial fibrosis.
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