Body fat, body fat distribution, lean body mass and atrial fibrillation and flutter. A Danish cohort study
Key result
Higher body fat mass was associated with an increased risk of incident atrial fibrillation (HR 1.29; 95% CI, 1.24-1.33 per 1 SD increment), as was higher lean body mass.
Why the study?
Are higher body fat mass and higher lean body mass associated with an increased risk of incident atrial fibrillation or flutter in adults aged 50-64?
Population
55,273 men and women 50-64 years of age at recruitment from the Danish population-based prospective cohort…
Design
Cohort
Follow-up
median 13.5 years
Authors
Discussion
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Implication
Supports body composition assessment in AF risk models; extends BMI data but remains hypothesis-generating.
Study Design
Type
Cohort (n=55,273)
Structured PICO
Are higher body fat mass and higher lean body mass associated with an increased risk of incident atrial fibrillation or flutter in adults aged 50-64?
P
Population
55,273 men and women aged 50-64 years followed for a median of 13.5 years to assess the risk of incident atrial fibrillation or flutter.
E
Exposure
Higher body fat mass and higher lean body mass (measured via bioelectrical impedance and anthropometry)
O
Outcome
Incident record of atrial fibrillation or flutter (AF) in the Danish Registry of Patientshard clinical
Main Result
Hazard Ratio: 1.29 (95% CI 1.24–1.33)
Both higher body fat mass and higher lean body mass are independently associated with an increased risk of incident atrial fibrillation or flutter.
Cite This Study
Frost et al. (2014) conducted a cohort in Atrial fibrillation and flutter (n=55,273). Body fat mass (per 1 SD increment) vs. Lower body fat mass was evaluated on Incident record of atrial fibrillation or flutter (HR 1.29, 95% CI 1.24-1.33). Higher body fat mass was associated with an increased risk of incident atrial fibrillation (HR 1.29; 95% CI, 1.24-1.33 per 1 SD increment), as was higher lean body mass.