Key result
Natural plant products may alleviate doxorubicin-induced cardiomyopathy by inhibiting ferroptosis and reducing oxidative stress.
Why the study?
Clinical use of doxorubicin is greatly limited by cardiotoxicity, and mechanisms of doxorubicin-induced cardiomyopathy—closely tied to ferroptosis—are not fully understood.
Do plant-derived natural active compounds mitigate doxorubicin-induced cardiotoxicity by inhibiting ferroptosis?
Do plant-derived natural active compounds mitigate doxorubicin-induced cardiotoxicity by inhibiting ferroptosis?
Plant-derived natural compounds offer a promising therapeutic strategy to mitigate doxorubicin-induced cardiomyopathy by targeting ferroptosis.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for plant compounds in doxorubicin cardiomyopathy; prospective trials needed before clinical adoption.
Doxorubicin (DOX) is a chemotherapy drug widely used in clinical settings, acting as a first-line treatment for various malignant tumors. However, its use is greatly limited by the cardiotoxicity it induces, including doxorubicin-induced cardiomyopathy (DIC). The mechanisms behind DIC are not fully understood, but its potential biological mechanisms are thought to include oxidative stress, inflammation, energy metabolism disorders, mitochondrial damage, autophagy, apoptosis, and ferroptosis. Recent studies have shown that cardiac injury induced by DOX is closely related to ferroptosis. Due to their high efficacy, availability, and low side effects, natural medicine treatments hold strong clinical potential. Currently, natural medicines have been shown to mitigate DOX-induced ferroptosis and ease DIC through various functions such as antioxidation, iron ion homeostasis correction, lipid metabolism regulation, and mitochondrial function improvement. Therefore, this review summarizes the mechanisms of ferroptosis in DIC and the regulation by natural plant products, with the expectation of providing a reference for future research and development of inhibitors targeting ferroptosis in DIC. This review explores the mechanisms of ferroptosis in doxorubicin-induced cardiomyopathy (DIC) and summarizes how natural plant products can alleviate DIC by inhibiting ferroptosis through reducing oxidative stress, correcting iron ion homeostasis, regulating lipid metabolism, and improving mitochondrial function.
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Wang et al. (2024) conducted a review in Doxorubicin-induced cardiomyopathy (DIC). Plant-derived natural active compounds was evaluated. Natural plant products can alleviate doxorubicin-induced cardiomyopathy by inhibiting ferroptosis through reducing oxidative stress, correcting iron ion homeostasis, and improving mitochondrial function.
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